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There are several types of antibodies and antigens, and each antibody is capable of binding only to a specific antigen. The specificity of the binding is due to specific chemical constitution of each antibody. The antigenic determinant or epitope is recognized by the paratope of the antibody, situated at the variable region of the polypeptide ...
FastContact is an algorithm for the rapid estimate of contact and binding free energies for protein–protein complex structures. It is based on a statistically determined desolvation contact potential and Coulomb electrostatics with a distance-dependent dielectric constant. The application also reports residue contact free energies that ...
Molecular binding occurs in biological complexes (e.g., between pairs or sets of proteins, or between a protein and a small molecule ligand it binds) and also in abiologic chemical systems, e.g. as in cases of coordination polymers and coordination networks such as metal-organic frameworks.
Using the "lock and key model" of enzyme binding, a drug (key) must be of roughly the proper dimensions to fit the enzyme's binding site (lock). [28] Using the appropriately sized molecular scaffold, drugs must also interact with the enzyme non-covalently in order to maximize binding affinity binding constant and reduce the ability of the drug ...
The chemical intuition suggests that the glycan-binding sites may be enriched in polar amino acid residues that form non-covalent interactions, such as hydrogen bonds, with polar carbohydrates. Indeed, a statistical analysis of carbohydrate-binding pockets shows that aspartic acid and asparagine residues are present twice as often as would be ...
6634 67332 Ensembl ENSG00000100028 ENSMUSG00000020180 UniProt P62318 P62320 RefSeq (mRNA) NM_001278656 NM_004175 NM_026095 RefSeq (protein) NP_001265585 NP_004166 NP_080371 Location (UCSC) Chr 22: 24.56 – 24.58 Mb Chr 10: 75.35 – 75.37 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene ...
In practice, the n value of a ligand is not indicated explicitly but rather assumed. The binding affinity of a chelating system depends on the chelating angle or bite angle. Denticity (represented by κ) is nomenclature that described to the number of noncontiguous atoms of a ligand bonded to a metal. This descriptor is often omitted because ...
Given an element of a disjoint union A + B, it is possible to determine whether it came from A or B. If an element lies in both, there will be two effectively distinct copies of the value in A + B, one from A and one from B. In type theory, a tagged union is called a sum type. Sum types are the dual of product types.