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RefSeq Select: This project aims to select datasets of RefSeq Select transcripts, as the most representative for every protein-coding gene, based on multiple criteria: prior use in clinical databases, transcript expression, evolutionary conservation of the coding region etc.
54790 214133 Ensembl ENSG00000168769 ENSMUSG00000040943 UniProt Q6N021 Q4JK59 RefSeq (mRNA) NM_001127208 NM_017628 NM_001040400 NM_145989 NM_001346736 RefSeq (protein) NP_001120680 NP_060098 NP_001035490 NP_001333665 Location (UCSC) Chr 4: 105.15 – 105.28 Mb Chr 3: 133.17 – 133.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tet methylcytosine dioxygenase 2 (TET2) is a human ...
c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc. In cancer, c-myc is often constitutively (persistently) expressed. This leads to the increased expression of many genes, some of which are involved in cell proliferation, contributing to the formation of ...
Expression data can be used to infer gene regulation: one might compare microarray data from a wide variety of states of an organism to form hypotheses about the genes involved in each state. In a single-cell organism, one might compare stages of the cell cycle , along with various stress conditions (heat shock, starvation, etc.).
[131] [132] Weighted gene co-expression network analysis has been successfully used to identify co-expression modules and intramodular hub genes based on RNA seq data. Co-expression modules may correspond to cell types or pathways. Highly connected intramodular hubs can be interpreted as representatives of their respective module.
EZH2, as a part of PRC2, catalyzes trimethylation of H3K27 (), which is a histone modification that has been characterized as part of the histone code.[16] [20] [21] [22] The histone code is the theory that chemical modifications, such as methylation, acetylation, and ubiquitination, of histone proteins play distinctive roles in epigenetic regulation of gene transcription.
In this case there is no separate "gene of interest"; the reporter gene is simply placed under the control of the target promoter and the reporter gene product's activity is quantitatively measured. The results are normally reported relative to the activity under a "consensus" promoter known to induce strong gene expression. [24]
There is high expression in the lymph node, spleen, and thymus. [15] There is significant expression in the brain , bladder , epididymis , and the helper T cell . [ 15 ] Therefore, there is statistically significant expression of C12orf42 gene throughout the nervous system , immune system , and male reproductive system .