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Antiglucocorticoid drugs are a class of medications that act to reduce the effects of glucocorticoids, primarily cortisol, in the body. [1] They include direct glucocorticoid receptor antagonists such as mifepristone and synthesis inhibitors such as metyrapone, ketoconazole, and aminoglutethimide. They are used to treat Cushing's syndrome. [2]
Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor [1] that is present in almost every vertebrate animal cell. The name "glucocorticoid" is a portmanteau ( gluco se + cort ex + ster oid ) and is composed from its role in regulation of glucose metabolism , synthesis in the adrenal cortex , and its steroidal structure ...
Most esters of these corticosteroids are not included in this list; for esters, see here instead. The most common structural modifications in synthetic corticosteroids include 1(2)-dehydrogenation, 6α-, 9α-, 16α-, and 16β-substitution (with a halogen or methyl group), 16α,17α-acetonidation, and 17α- and 21-esterification.
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones.Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism ...
Adrenal steroids such as glucocorticoids and mineralocorticoids are commonly used as treatments in diseases such as Congenital adrenal hyperplasia. [2] CAH commonly causes overproduction of androgens, glucocorticoid treatment is used to reduce Adrenocorticotropic hormone (ACTH) and reduce the production of androgens allowing for symptoms of CAH to be managed though treatment is required to be ...
Prednisolone is a corticosteroid drug with predominant glucocorticoid and low mineralocorticoid activity, making it useful for the treatment of a wide range of inflammatory and autoimmune conditions [17] such as asthma, [18] uveitis, pyoderma gangrenosum, rheumatoid arthritis, urticaria, [19] angioedema, [19] ulcerative colitis, pericarditis ...
Beclometasone dipropionate, an example of a widely used corticosteroid ester. Note the propionate groups at the C17α and C21α positions (top right corner). This is a list of corticosteroid esters, including esters of steroidal glucocorticoids and mineralocorticoids. [1] [2] [3]
Topical glucocorticoid phobia is a concern or fear about using topical glucocorticoids, which is commonly found among patients with atopic dermatitis and their caregivers. [29] This phenomenon has been identified in more than 15 countries globally, including Canada , France , Japan , the United Kingdom , and the United States . [ 30 ]