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Differential diagnosis: Sleep apnea, major depressive disorder, ... Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake ...
Furthermore, pediatric diagnoses are not distinguished from adult diagnoses except for sleep-related breathing disorders. [8] In addition, significant changes have been made in the nosology of insomnia, narcolepsy and parasomnia. Primary vs. secondary (i.e. comorbid) insomnia has been reunited into a single disorder: chronic insomnia.
In the appropriate context, more than 1 SOREMP between the preceding PSG and the MSLT may support a diagnosis of narcolepsy. Results must be interpreted cautiously as comorbid sleep disorders, medications, or recreational drug use can affect REM sleep onset. [10]
Behaviorally induced insufficient sleep syndrome must be considered in the differential diagnosis of secondary hypersomnia. This disorder occurs in individuals who fail to get sufficient sleep for at least three months. In this case, the patient has chronic sleep deprivation, although they may not necessarily be aware of it. This situation is ...
It is also important to note that whereas narcolepsy is strongly associated with the HLA-DQB1*0602 genotype, [20] "HLA typing is of no help in the positive diagnosis of idiopathic hypersomnia." [18] This is "despite some reports that suggest an increase [sic] frequency of HLA Cw2 and DRS in idiopathic hypersomnia subjects." [18]
Pediatric narcolepsy cases are cases when patients are diagnosed or experience symptoms onset for narcolepsy before the age of 18. Of patients who obtain a formal diagnosis for narcolepsy, more than 50% report first experiencing symptoms of narcolepsy more than 10 years before their formal diagnosis, with an average age of symptom onset being at age 15 and symptom onset most likely to occur ...
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