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Tetracyclines are generally used in the treatment of infections of the urinary tract, respiratory tract, and the intestines and are also used in the treatment of chlamydia, especially in patients allergic to β-lactams and macrolides; however, their use for these indications is less popular than it once was due to widespread development of resistance in the causative organisms.
Tetracycline hydrochloride is available as yellow crystalline powder. Since tetracycline is absorbed into bone, it is used as a marker of bone growth for biopsies in humans. Tetracycline labeling is used to determine the amount of bone growth within a certain period of time, usually a period around 21 days.
The overall structure of TetR can be broken down into two DNA-binding domains (one per monomer) and a regulatory core, which is responsible for tetracycline recognition and dimerization. TetR dimerizes by making hydrophobic contacts within the regulatory core. There is a binding cavity for tetracycline in the outer helices of the regulatory domain.
Pages in category "Tetracycline antibiotics" The following 20 pages are in this category, out of 20 total. This list may not reflect recent changes. ...
The structure of tetracenomycin C was established by chemical and spectroscopic methods. [3] The three hydroxy groups, at C-4, C-4a, and C-12a, are cis to each other. The two at C-4a and C-12a are involved in intramolecular hydrogen bonding to the carbonyl oxygen atoms at C-5 and C-1, respectively.
Doxycycline, a tetracyclic antibiotic. Mirtazapine, a tetracyclic antidepressant. Tetracyclics are cyclic chemical compounds that contain four fused rings of atoms, for example, Tröger's base.
Tetracycline; Doxycycline This page was last edited on 15 February 2021, at 05:41 (UTC). Text is available under the Creative Commons Attribution-ShareAlike 4.0 ...
Oxytetracycline, like other tetracyclines, is used to treat many infections, both common and rare.Its better absorption profile makes it preferable to tetracycline for moderately severe acne at a dosage of 250–500 mg four times a day for usually six to eight weeks at a time, but alternatives should be sought if no improvement occurs by three months.