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Comedocarcinoma is a kind of breast cancer that demonstrates comedonecrosis, which is the central necrosis [1] of cancer cells within involved ducts. Comedocarcinomas are usually non-infiltrating and intraductal tumors, characterized as a comedo-type, high-grade ductal carcinoma in situ (DCIS).
(B) Cribiform comedo-type carcinoma: Cribriform gland (yellow arrow) with central necrosis comedo-like (yellow asterisk). (C) Micropapillary carcinoma : Small, tight round to oval cohesive clusters of neoplastic cells (>5 cells) floating in clear spaces (double circle red-black), without endothelial lining and with no evidence of inflammatory ...
PDCIS tissues may also contain areas of "Comedo-type necrosis", i.e. areas where dead cells have accumulated. [6] An Immunohistochemical study conducted in 2009 of 54 individuals diagnosed with PDCIS found that the tumor cells in 34, 31, and 35 cases, respectively, expressed the estrogen receptor, progesterone receptor, and HER2/neu protein. [14]
Subcutaneous fat necrosis of the newborn: Peanut agglutinin: Basal cell carcinoma: Phosphotungsten acid-hematoxylin (PTAH) Infantile digital fibromatosis: Pogoda red: Amyloidosis: Protein gene product 9.5 (PGP9.5) Nerve sheath myxoma: Silver nitrate: Urate crystal: Gout: Sirius red: Amyloidosis: Smooth muscle actin (SMA) Angiomyxoma ...
A comedo (plural comedones) is a clogged hair follicle (pore) in the skin. [2] Keratin (skin debris) combines with oil to block the follicle. [ 3 ] A comedo can be open ( blackhead ) or closed by skin ( whitehead ) and occur with or without acne . [ 3 ]
In pathology, ghost cells are often associated with certain types of tumors, such as pilomatricomas and calcifying odontogenic cysts, where they appear as pale, anucleate cells that have undergone degeneration or calcification. The ghost cells indicate coagulative necrosis where there is cell death but retainment of cellular architecture. In ...
Caseous necrosis or caseous degeneration [1] (/ ˈ k eɪ s i ə s /) [2] is a unique form of cell death in which the tissue maintains a cheese-like appearance. [3] Unlike with coagulative necrosis, tissue structure is destroyed. Caseous necrosis is enclosed within a granuloma. Caseous necrosis is most notably associated with tuberculoma. The ...
[1] [2] The effect is well known in diagnostic surgical pathology. [3] The phenomenon is named after the pathologist, John G. Azzopardi. [4] [5] [6] Azzopardi was able to correctly characterize the effect as due to DNA; it had been thought previously but incorrectly to be calcium. [4]