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Together with Alexander Rudensky, Janeway also characterized how self antigens associate with MHC class II molecules. [6] Janeway is particularly well known as the lead author of Immunobiology, a standard textbook on immunology. Since the 2008 publishing of its seventh edition, it has been renamed as Janeway's Immunobiology in his memory. [7]
The clonal selection theory can be summarised with the following four tenets: Each lymphocyte bears a single type of receptor with a unique specificity (generated by V(D)J recombination).
The 8th edition of Janeway's Immunobiology defines tolerance as "immunologically unresponsive...to another's tissues.". [2] Immune tolerance encompasses the range of physiological mechanisms by which the body reduces or eliminates an immune response to particular agents.
Scheme of the complement system. The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. [1]
Immunology is a branch of biology and medicine [1] that covers the study of immune systems [2] in all organisms.. Immunology charts, measures, and contextualizes the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders (such as autoimmune diseases, hypersensitivities, [3] immune deficiency, [4] and ...
The classical complement pathway can be initiated by the binding of antigen-antibody complexes to the C1q protein. The globular regions of C1q recognize and bind to the Fc region of antibody isotypes IgG or IgM. [2]
In immunology, antibodies (immunoglobulins (Ig)) are classified into several types called isotypes or classes.The variable (V) regions near the tip of the antibody can differ from molecule to molecule in countless ways, allowing it to specifically target an antigen (or more exactly, an epitope).
Janeway, Travers, Walport, Shlomchik, Immunobiology 6th ed. (2005) Garland Science:NY Parham, Peter, The Immune System 3rd ed. (2009) Garland Science: London and New York Davignon D, Martz E, Reynolds T, Kürzinger K, Springer TA (July 1981).