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Diabetic cardiomyopathy is a disorder of the heart muscle in people with diabetes. It can lead to inability of the heart to circulate blood through the body effectively, a state known as heart failure (HF), [ 2 ] with accumulation of fluid in the lungs ( pulmonary edema ) or legs ( peripheral edema ).
Patrick Vallance and his London co-workers first noted the interference role for asymmetric dimethylarginine in the early 1990s. [1] Today biochemical and clinical research continues into the role of ADMA in cardiovascular disease, diabetes mellitus, erectile dysfunction and certain forms of kidney disease.
[1] [2] Chemically, it is a methyl derivative of the amino acid arginine. It is used as a biochemical tool in the study of physiological role of nitric oxide . The inhibiting effect of N -methylarginine on vasodilation is lower in hypertensive patients than in normal subjects, indicating endothelial dysfunction . [ 3 ]
L-Arginine:glycine amidinotransferase (AGAT; EC 2.1.4.1) is the enzyme that catalyses the transfer of an amidino group from L-arginine to glycine. The products are L-ornithine and glycocyamine, also known as guanidinoacetate, the immediate precursor of creatine. Creatine and its phosphorylated form play a central role in the energy metabolism ...
The administration of L-arginine during the acute and interictal periods is recommended. [15] Doing so may reduce brain damage due to impairment of vasodilation in intracerebral arteries due to nitric oxide depletion. [16] [17] Citrulline is also used as citrulline makes the plasma arginine higher, though the dosage is still being studied at ...
It is structurally equivalent to a one-methylene group-higher homolog of arginine and to the guanidino derivative of lysine. L -Homoarginine is the naturally-occurring enantiomer . Physiologically , homoarginine increases nitric oxide (NO) supply and betters endothelial functions in the body, with a particular correlation and effect towards ...