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TMP/SMX is commonly used due to its ability to achieve high concentrations in urinary tract tissues and urine. This antibiotic combination demonstrates notable efficacy in both the treatment and prophylaxis of recurrent urinary tract infections. [12] Common adverse effects include nausea, vomiting, rash,pruritus, and photosensitivity. [26]
The drug's spectrum of antibacterial activity includes all urinary tract pathogens. [30] [2] It is specifically effective against common UTI-causing bacteria including Staphylococcus saprophyticus, Escherichia coli, Enterococcus faecalis, and Enterococcus faecium.
Urinary tract infections may affect 10% of people during childhood. [7] Among children, urinary tract infections are most common in uncircumcised males less than three months of age, followed by females less than one year. [28] Estimates of frequency among children, however, vary widely.
Nitrofurantoin, sold under the brand name Macrobid among others, is an antibacterial medication of the nitrofuran class used to treat urinary tract infections (UTIs), although it is not as effective for kidney infections. [16] It is taken by mouth. [16] Common side effects include nausea, loss of appetite, diarrhea, and headaches. [16]
Urinary tract infections, bacterial prostatitis, community-acquired pneumonia, bacterial diarrhea, mycoplasmal infections, gonorrhea: Nausea (rare), irreversible damage to central nervous system (uncommon), tendinosis (rare) Inhibits the bacterial DNA gyrase or the topoisomerase IV enzyme, thereby inhibiting DNA replication and transcription ...
A 2023 study that got a lot of buzz estimated that E.coli-contaminated meat leads to nearly half a million UTIs in the U.S. each year, making it one of the most common causes of UTIs.