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For example, an overactive distal promoter located about 1 kilobase away from the MUC5B gene contributes to atypical expression of this gene in gastric cancer cells. [4] Similarly, a few polymorphisms in the RUNX3 distal promoter alter the promoter's function, increasing the activity of the NF-κB transcription factor and the expression of the ...
Distal promoters also frequently contain CpG islands, such as the promoter of the DNA repair gene ERCC1, where the CpG island-containing promoter is located about 5,400 nucleotides upstream of the coding region of the ERCC1 gene. [54] CpG islands also occur frequently in promoters for functional noncoding RNAs such as microRNAs.
Distal promoter elements also frequently contain CpG islands. An example is the DNA repair gene ERCC1, where the CpG island-containing element is located about 5,400 nucleotides upstream of the transcription start site of the ERCC1 gene. [22] CpG islands also occur frequently in promoters for functional noncoding RNAs such as microRNAs. [23]
Promoter/enhancer connections: distal cis-regulatory elements, such as enhancers are in charge of modulating the activity of the promoters. In this way, the distal cis-regulatory elements are actively synchronized with their promoter in the cellular lines which is active the expression of the gene controlled. Using the DHS profiles, were looked ...
When they are located farther away from the promoter, insulator elements would compete with the enhancer and interfere with activation of transcription. [3] Loop formation is common in eukaryotes to bring distal elements (enhancers, promoters, locus control regions) into closer proximity for interaction during transcription. [4]
Intergenic regions may contain a number of functional DNA sequences such as promoters and regulatory elements, enhancers, spacers, and (in eukaryotes) centromeres. [2] They may also contain origins of replication, scaffold attachment regions, and transposons and viruses.
Genes may also have distant promoters (distal promoters) and these frequently contain CpG islands as well. An example is the promoter of the DNA repair gene ERCC1, where the CpG island-containing promoter is located about 5,400 nucleotides upstream of the coding region of the ERCC1 gene. [5]
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 ...