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White matter is the tissue through which messages pass between different areas of grey matter within the central nervous system. The white matter is white because of the fatty substance (myelin) that surrounds the nerve fibers (axons). This myelin is found in almost all long nerve fibers, and acts as an electrical insulation.
White matter fibre dissection is nowadays considered as a valuable tool to enhance our knowledge about brain connectivity, [5] [9] [10] [1] and has been used to validate tractographic results and vice versa with good consistency between the two techniques, [11] but also for neurosurgical training and neuroanatomical teaching.
The gray matter remains normal in all characteristics while the white matter changes texture, becoming soft and gelatinous. Rarefaction of the white matter is seen through light microscopy and the small number of axons and U-fibers that were affected can also be seen. Numerous small cavities in the white matter are also apparent.
The European Leukodystrophy Association also supports research into leukodystrophy. As of 2020, more than 387 research projects have been funded. Each year, ELA invites the international scientific community to submit research projects in the field of genetic leukodystrophies, the cerebral white matter in premature infants, and of myelin repair ...
Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis (more often coagulation) of white matter near the lateral ventricles.
In neuroanatomy, the centrum semiovale, semioval center or centrum ovale [1] is the central area of white matter found underneath the cerebral cortex. [2] The white matter, located in each hemisphere between the cerebral cortex and nuclei, as a whole has a semioval shape.
The uncinate fasciculus is a white matter association tract in the human brain that connects parts of the limbic system such as the temporal pole, anterior parahippocampus, and amygdala in the temporal lobe with inferior portions of the frontal lobe such as the orbitofrontal cortex.
The localization of tumors in relation to the white matter tracts (infiltration, deflection), has been one of the most important initial applications. In surgical planning for some types of brain tumors , surgery is aided by knowing the proximity and relative position of the corticospinal tract and a tumor.