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  2. RIT2 - Wikipedia

    en.wikipedia.org/wiki/RIT2

    19762 Ensembl ENSG00000152214 ENSMUSG00000057455 UniProt Q99578 P70425 RefSeq (mRNA) NM_002930 NM_001272077 NM_009065 RefSeq (protein) NP_001259006 NP_002921 NP_033091 Location (UCSC) Chr 18: 42.74 – 43.12 Mb Chr 18: 31.11 – 31.45 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse GTP-binding protein Rit2 is a protein that in humans is encoded by the RIT2 gene. RIN belongs to the ...

  3. LRRK2 - Wikipedia

    en.wikipedia.org/wiki/LRRK2

    Mutations in this gene have been associated with Parkinson's disease type 8. [20] [21] The G2019S mutation results in enhanced kinase activity, and is a relatively common cause of familial Parkinson's disease in Caucasians. [22] It may also cause sporadic Parkinson's disease. The mutated Gly amino acid is conserved in all kinase domains of all ...

  4. Pathway analysis - Wikipedia

    en.wikipedia.org/wiki/Pathway_analysis

    Pathway resources and types of pathway analysis using databases like KEGG, Reactome and WikiPathways. [1]Pathway is the term from molecular biology for a curated schematic representation of a well characterized segment of the molecular physiological machinery, such as a metabolic pathway describing an enzymatic process within a cell or tissue or a signaling pathway model representing a ...

  5. Parkin (protein) - Wikipedia

    en.wikipedia.org/wiki/Parkin_(protein)

    Parkin is a 465-amino acid residue E3 ubiquitin ligase, a protein that in humans and mice is encoded by the PARK2 gene. [5] [6] Parkin plays a critical role in ubiquitination – the process whereby molecules are covalently labelled with ubiquitin (Ub) and directed towards degradation in proteasomes or lysosomes.

  6. Biochemical cascade - Wikipedia

    en.wikipedia.org/wiki/Biochemical_cascade

    Knowledge-driven pathway construction entails development of a detailed pathway knowledge base for particular domains of interest, such as a cell type, disease, or system. The curation process of a biological pathway entails identifying and structuring content, mining information manually and/or computationally, and assembling a knowledgebase ...

  7. Hes3 signaling axis - Wikipedia

    en.wikipedia.org/wiki/Hes3_signaling_axis

    This signaling pathway may mediate pro-survival functions of macrophage migration inhibitory factor on neural stem cells. [10] Activation of the signaling pathway by Delta4, Angiopoietin 2, insulin, or a combination of the three and a JAK inhibitor induces motor skill improvements in adult rat models of Parkinson's disease (6-hydroxydopamine ...

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