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  2. Pregabalin - Wikipedia

    en.wikipedia.org/wiki/Pregabalin

    Pregabalin is generally not regarded as efficacious in the treatment of acute pain. [50] In trials examining the utility of pregabalin for the treatment of acute post-surgical pain, no effect on overall pain levels was observed, but people did require less morphine and had fewer opioid-related side effects.

  3. Gabapentinoid - Wikipedia

    en.wikipedia.org/wiki/Gabapentinoid

    However, food has been found to substantially delay the absorption of pregabalin and to significantly reduce peak levels without affecting the bioavailability of the drug; T max values for pregabalin of 0.6 hours in a fasted state and 3.2 hours in a fed state (5-fold difference), and the C max is reduced by 25–31% in a fed versus fasted state ...

  4. Fibromyalgia - Wikipedia

    en.wikipedia.org/wiki/Fibromyalgia

    Approximately 6/10 people who take gabapentin to treat pain related to fibromyalgia experience unpleasant side effects such as dizziness, abnormal walking, or swelling from fluid accumulation. [180] Pregabalin demonstrates a benefit in about 9% of people. [181] Pregabalin reduced time off work by 0.2 days per week. [182]

  5. Difelikefalin - Wikipedia

    en.wikipedia.org/wiki/Difelikefalin

    It is under development by Cara Therapeutics as an intravenous agent for the treatment of postoperative pain. [10] [11] [13] An oral formulation has also been developed. [13]Due to its peripheral selectivity, difelikefalin lacks the central side effects like sedation, dysphoria, and hallucinations of previous KOR-acting analgesics such as pentazocine and phenazocine.

  6. Black Friday shoppers spent a record $10.8 billion online ...

    www.aol.com/black-friday-online-sales-track...

    People didn't just fill their plates this Thanksgiving weekend -- data shows they also filled their online shopping carts. Black Friday online shopping this year set a new high, reaching $10.8 ...

  7. Secret Santa gives thousands of dollars to North Carolina ...

    www.aol.com/secret-santa-gives-thousands-dollars...

    Avery County, North Carolina — Some people were skeptical, at first, of the stranger who rolled into flood-ravaged Avery County in western North Carolina this week claiming to be some kind of ...

  8. Health Canada - Wikipedia

    en.wikipedia.org/wiki/Health_Canada

    Health Canada (HC; French: Santé Canada, SC) [NB 1] is the department of the Government of Canada responsible for national health policy. The department itself is also responsible for numerous federal health-related agencies, including the Canadian Food Inspection Agency (CFIA) and the Public Health Agency of Canada (PHAC), among others.

  9. Fear in the C-Suite after UnitedHealthcare CEO gunned down - AOL

    www.aol.com/c-suites-fear-more-executives...

    The New York Police Department, in an intelligence report obtained by CNN Tuesday, said it believed Thompson’s killing was a “symbolic takedown” and could inspire others to act violently ...