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DNA origami object from viral DNA visualized by electron tomography. [1] The map is at the top and atomic model of the DNA colored below. (Deposited in EMDB EMD-2210) . DNA origami is the nanoscale folding of DNA to create arbitrary two- and three-dimensional shapes at the nanoscale.
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Among these devices are force-sensing nano-structures, [2] gigadalton-sized DNA assemblies, [3] dynamically switching devices, [4] molecular motors, [5] [6] and virus traps. [ 7 ] [ 8 ] In the long term, Dietz hopes to make a significant contribution to the creation of molecular machines and systems with practical benefits for everyday life.
In contrast, the SNA structure can be synthesized independent of nucleic acid sequence and hybridization, instead their synthesis relies upon chemical bond formation between nanoparticles and DNA ligands. Furthermore, DNA origami uses DNA hybridization interactions to realize a final structure, whereas SNAs and other forms of three-dimensional ...
These include examples such as DNA machines, periodic two- and three-dimensional lattices, polyhedra, and DNA origami. [2] It can also be used to create sets of nucleic acid strands which are "orthogonal", or non-interacting with each other, so as to minimize or eliminate spurious interactions.
Rothemund's DNA origami contains a long strand which folding is assisted by several short strands. This method allowed forming much larger structures than formerly possible, and which are less technically demanding to design and synthesize. [7] DNA origami was the cover story of Nature on March 15, 2006. [13]
1. Chocolate Fondue. Think of that fondue fountain at the buffet as Willy Wonka's sacred chocolate waterfall and river. The chocolate must go untouched by human hands, or it will be ruined.
The DNA model shown (far right) is a space-filling, or CPK, model of the DNA double helix. Animated molecular models, such as the wire, or skeletal, type shown at the top of this article, allow one to visually explore the three-dimensional (3D) structure of DNA. Another type of DNA model is the space-filling, or CPK, model.