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Cystic fibrosis (also known as CF or mucoviscidosis) is an autosomal recessive genetic disorder affecting most critically the lungs, and also the pancreas, liver, and intestine.
In cystic fibrosis, the CFTR chloride channel is defective, and does not allow chloride to be reabsorbed into sweat duct cells. Consequently, more sodium stays in the duct, and more chloride remains in the sweat. The concentration of chloride in sweat is therefore elevated in individuals with cystic fibrosis. The concentration of sodium in ...
Cystic fibrosis may also lead to arthropathies. [5] These symptoms and co-morbidities can ultimately lead to nutritional deficits and highly decreased quality of life. [6] Compared to white patients, black patients have more severe pulmonary imaging findings and display more respiratory
For the least active, moving up to the second group brought gains in life expectancy of 0.6 years, while going up to the third group added 3.5 years—corresponding to life expectancy at birth of ...
Cystic fibrosis: CF can cause skeletal muscle atrophy, however more commonly it can cause exercise intolerance. The exercise intolerance is associated with reduced pulmonary function that is the origin of CF. [4] Bronchiectasis
Reviews of neuroimaging studies indicate that consistent aerobic exercise increases gray matter volume in nearly all regions of the brain, [31] with more pronounced increases occurring in brain regions associated with memory processing, cognitive control, motor function, and reward; [1] [5] [31] the most prominent gains in gray matter volume are seen in the prefrontal cortex, caudate nucleus ...
The diagnosis of cystic fibrosis (CF) is usually based on high chloride concentrations in sweat, characteristic clinical findings (including sinopulmonary infections), and/or family history. However, a small portion of patients with cystic fibrosis, especially those with "mild" mutations of the cystic fibrosis transmembrane regulator (CFTR) ion ...
However, there are more than 2,000 known mutations, so gene panel testing does miss occasional CF patients. [medical citation needed] If gene testing finds one mutation they will then have a sweat test to help confirm the diagnosis. Sweat testing is more likely to be equivocal in infants and typically not attempted in those under 5 kg.