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Dakin's solution is a dilute solution of sodium hypochlorite (0.4% to 0.5%) and other stabilizing ingredients, traditionally used as an antiseptic, e.g. to cleanse wounds in order to prevent infection. [1] The preparation was for a time called also Carrel–Dakin solution or Carrel–Dakin fluid. [2]
The company's flagship product is Tecnu, a cleanser which prevents the oils which cause poison oak rash from bonding to the skin. The product line of Tec Laboratories has gradually grown to include additional over-the-counter skin preparations, insect repellents, head lice treatments, [8] and wound care preparations. The firm has expanded from ...
During the 1960s, both were available over the counter in the US. After the ban, pHisoDerm was reformulated without hexachlorophene, and continued to be sold over-the-counter, while pHisoHex , (which contained 3% hexachlorophene - 3 times the legal limit imposed in 1972), [ 7 ] became available as a prescription body wash.
Chlorhexidine came into medical use in the 1950s [15] and is available over the counter in the United States. [9] It is on the World Health Organization's List of Essential Medicines. [16] In 2022, it was the 230th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [17] [18]
For these purposes PVP-I has been formulated at concentrations of 7.5–10.0% in solution, spray, surgical scrub, ointment, and swab dosage forms; however, use of 10% povidone-iodine though recommended, is infrequently used, as it is poorly accepted by health care workers and is excessively slow to dry. [11] [12]
Merbromin's best-known use is as a topical antiseptic to treat minor wounds, burns, and scratches. [3] It is also used in the antisepsis of the umbilical cord, [4] and the antisepsis of wounds with inhibited scar formation, such as neuropathic ulcers and diabetic foot sores. [5]
OTC (over the counter) products containing cetylpyridinium chloride include oral wash, oral rinse, and ingestable products, such as lozenges [8] and over-the-counter cough syrup. [9] The United States' federal Food and Drug Administration's monograph on oral antiseptic drug products reviewed the data regarding CPC and made this conclusion:
The combination is available over the counter in the US and Canada. [5] In 2021, it was the 376th most commonly prescribed medication in the United States, with more than 25,000 prescriptions. [ 6 ]
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