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Prurigo nodularis (PN), also known as nodular prurigo, is a skin disorder characterized by pruritic , nodular lesions, which commonly appear on the trunk, arms and legs. [1] Patients often present with multiple excoriated nodules caused by chronic scratching.
In May 2022, the indication for dupilumab was updated to include the treatment of eosinophilic esophagitis in people aged twelve years of age and older weighing at least 40 kilograms (88 lb). [9] In September 2022, the indication for dupilumab was updated to include the treatment of adults with prurigo nodularis (PN). [10]
Nemolizumab is indicated for the treatment of adults with prurigo nodularis. [1] [4] In December 2024, the indication for nemolizumab was updated to include the treatment of people twelve years of age and older with moderate-to-severe atopic dermatitis in combination with topical corticosteroids and/or calcineurin inhibitors when the disease is not adequately controlled with topical ...
The FDA grants priority review to Sanofi's (SNY) sBLA for Dupixent to include adults with prurigo nodularis, a chronic inflammatory skin disease.
Also in June 2022, Galderma announced positive data from Phase III trial, showing efficacy and safety of nemolizumab in patients with prurigo nodularis. Nemolizumab is a monoclonal antibody that blocks the signaling of IL-31, a neuroimmune cytokine involved in the pathogenesis of prurigo nodularis. [14] [15]
Treatment of adults with Prurigo Nodularis [2] Nogapendekin alfa inbakicept: Indicated with Bacillus Calmette-Guérin (BCG) for the treatment of adults with BCG-unresponsive nonmuscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without papillary tumors [2] Olezarsen: Ionis Pharmaceuticals