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Palmitoylation of Gephyrin Controls Receptor Clustering and Plasticity of GABAergic Synapses [1] In molecular biology, palmitoylation is the covalent attachment of fatty acids, such as palmitic acid, to cysteine (S-palmitoylation) and less frequently to serine and threonine (O-palmitoylation) residues of proteins, which are typically membrane ...
Palmitoylation. S-palmitoylation (i.e. attachment of palmitic acid) is a reversible protein modification in which a palmitic acid is attached to a specific cysteine residue via thioester linkage. [2] [11] The term S-acylation can also be used when other medium and long fatty acids chains are also attached to palmitoylated proteins.
Further studies in 2009 showed that of the 5 classes studied, 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one was shown to behave similarly to 2-Bromopalmitate and were identified as able to inhibit the palmitoylation reaction of a range of DHHC domain containing proteins.
palmitoylation (a type of acylation), attachment of palmitate, a C 16 saturated acid; isoprenylation or prenylation, the addition of an isoprenoid group (e.g. farnesol and geranylgeraniol) farnesylation; geranylgeranylation; glypiation, glycosylphosphatidylinositol (GPI) anchor formation via an amide bond to C-terminal tail
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Nearly a decade after controversial reality show Gigolos went off the air, a new docuseries is set to cover the violent death of a woman at the hands of one of the show's former stars.. Gigolos ...
The protein palmitoylation is a reversible process. The addition of palmitoyl group increase the membrane association of the substrate protein while the removal by palmitoyl thioesterase decreases the membrane association.