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Nonsense Mutation Definition. A nonsense mutation occurs when the sequence of nucleotides in DNA is changed in a way that stops the normal sequence of amino acids in the final protein. In central dogma of biology, DNA is transposed into RNA, which is then translated into a protein.
A nonsense mutation, or its synonym, a stop mutation, is a change in DNA that causes a protein to terminate or end its translation earlier than expected. This is a common form of mutation in humans and in other animals that causes a shortened or nonfunctional protein to be expressed.
In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a nonsense codon, or a premature stop codon in the transcribed mRNA, and leads to a truncated, incomplete, and possibly nonfunctional protein product. [1]
What is a nonsense mutation? Like a missense mutation, a nonsense mutation also involves a single alteration to the DNA base pair. However, in the case of a nonsense mutation, this single change results in the production of a stop codon, thereby terminating protein synthesis prematurely.
A nonsense mutation is a genetic mutation in a DNA sequence that results in a shorter, unfinished protein product.
Biology definition: A nonsense mutation is a type of mutation resulting in a nonsense codon. The nonsense codon, as the name implies, would not code for an amino acid. A possible outcome is a protein product that is early truncated, incomplete, and often nonfunctional.
A nonsense mutation is a type of mutation where a premature stop codon is added to a sequence which hinders the further translation of the protein-coding gene. The nonsense mutation is classified as a loss-of-function change where the mutation impairs the production of a particular protein.
Explore the mechanisms, detection, and genetic implications of nonsense mutations and their role in protein synthesis and genetic disorders.
Definition of Nonsense Mutation. A nonsense mutation is a genetic alteration that introduces a premature stop codon into the coding sequence of a gene, leading to the production of a truncated and often nonfunctional protein.
A nonsense mutation is a genetic mutation in a DNA sequence that results in a shorter, unfinished protein product.