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Contents. Paracetamol. Paracetamol (acetaminophen[ a ]) is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. [ 14 ][ 15 ][ 16 ] It is a widely used over-the-counter medication. Common brand names include Tylenol and Panadol.
Paracetamol toxicity is one of the most common causes of poisoning worldwide. [25] In the United States, the United Kingdom, Australia, and New Zealand, paracetamol is the most common cause of drug overdoses. [20] [92] [93] Additionally, in both the United States and the United Kingdom it is the most common cause of acute liver failure. [94] [9]
Paracetamol (acetaminophen) Paracetamol, also known as acetaminophen or APAP, is a medication used to treat pain and fever. [6] It is typically used for mild to moderate pain. [6] In combination with opioid pain medication, paracetamol is now used for more severe pain such as cancer pain and after surgery. [7]
Paracetamol (acetaminophen) class antipyretics, which have negligible anti-inflammatory activity. Apart from paracetamol itself, the medications in this class are mainly previously marketed drugs which were withdrawn owing to safety concerns, one example of this being phenacetin. A few other medications have antipyretic effects of varying strength.
Acetylcysteine. N-acetylcysteine, also known as Acetylcysteine and NAC, is a medication that is used to treat paracetamol (acetaminophen) overdose and to loosen thick mucus in individuals with chronic bronchopulmonary disorders such as pneumonia and bronchitis. [9] It has been used to treat lactobezoar in infants.
It is available in combination with paracetamol (acetaminophen). As is typical of opioids, common side effects include constipation, itchiness, and nausea. [3] Serious side effects may include hallucinations, seizures, increased risk of serotonin syndrome, decreased alertness, and drug addiction. [3]
Recreational use is common in the United States. [4] [5] Common side effects include dizziness, sleepiness, constipation, and vomiting. [1] [3] Serious side effects include addiction, decreased rate of breathing, low blood pressure, severe allergic reactions, and liver failure. [1] Use during pregnancy may harm the fetus. [1]
Ibuprofen/paracetamol. Ibuprofen/paracetamol, sold under the brand name Combogesic among others, is a fixed-dose combination of two medications, ibuprofen, a non-steroidal anti-inflammatory drug (NSAID); and paracetamol (acetaminophen), an analgesic and antipyretic. [6] It is available as a generic medication. [9][10][11]