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Side effects of oral minoxidil may include swelling of the face and extremities, rapid heartbeat, or lightheadedness. Cardiac lesions, such as focal necrosis of the papillary muscle and subendocardial areas of the left ventricle, have been observed in laboratory animals treated with minoxidil. [ 8 ]
Serious side effects from minoxidil aren’t very common. When side effects do occur, they tend to be issues like itching, irritated skin or redness. Minoxidil doesn’t cause sexual side effects.
Minoxidil sulfate is formed from minoxidil via sulfotransferase enzymes, with the predominant enzyme responsible, at least in hair follicles, being SULT1A1. [ 1 ] [ 2 ] Minoxidil sulfate acts as a potassium channel opener , among other actions, and has vasodilating , hypotensive , and trichogenic or hypertrichotic (hair growth-promoting) effects.
Avoids internal side effects of oral minoxidil. Can be used with other topical hair-loss medications. May be an enjoyable part of a haircare routine. Potential side effects of topical minoxidil:
Finasteride and minoxidil are usually first line therapy for its treatment. Other options include topical or systemic spironolactone or flutamide, although they have a high incidence of feminising side effects and are better tolerated in female androgenic hair loss.
Treatment must be continued indefinitely. If the treatment is stopped, hair loss resumes. Any regrown hair and any hair susceptible to being lost, while Minoxidil was used, will be lost. Most frequent side effects are mild scalp irritation, allergic contact dermatitis, and unwanted hair in other parts of the body. [32]
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