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The specific kidney injuries induced by analgesics are renal papillary necrosis and chronic interstitial nephritis. They appear to result from decreased blood flow to the kidney, rapid consumption of antioxidants, and subsequent oxidative damage to the kidney. This kidney damage may lead to progressive chronic kidney failure, abnormal ...
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Chronic use of phenacetin is known to lead to analgesic nephropathy characterized by renal papillary necrosis. [14] [15] [16] This is a condition which results in destruction of some or all of the renal papillae in the kidneys. It is believed that the metabolite p-phenetidine is at least partly responsible for these effects. [17]
Risk for heart valve damage. [2] Perhexiline: 1985 UK, Spain Neurologic and hepatic toxicity. [3] Phenacetin: 1975 Canada An ingredient in "A.P.C." tablet; withdrawn because of risk of cancer and kidney disease [42] Germany Denmark, UK, US, others Reason: nephropathy. [3] Phenformin and Buformin: 1977 France, Germany US Severe lactic acidosis ...
NSAID identification on label of generic ibuprofen, an over-the-counter non-steroidal anti-inflammatory drug. Non-steroidal anti-inflammatory drugs [1] [3] (NSAID) [1] are members of a therapeutic drug class which reduces pain, [4] decreases inflammation, decreases fever, [1] and prevents blood clots.
The drug should, therefore, not be used in horses that are dehydrated or experiencing kidney failure. It should be used with caution in horses with liver problems or electrolyte abnormalities. Overdose may lead to dehydration, change in drinking patterns and urination, seizures, gastrointestinal problems, kidney damage, lethargy, collapse, and ...
Cost: $7 | Active ingredients: Lidocaine | Type: Cream | Amount: 4.3 ounces. Lidocaine is another popular ingredient found in pain relief creams. It's a topical anesthetic that's often used to ...
Anti-inflammatory drugs, also called anti-inflammatories, make up about half of analgesics. These drugs remedy pain by reducing inflammation as opposed to opioids , which affect the central nervous system to block pain signaling to the brain.