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In August 2020, the U.S. Food and Drug Administration (FDA) became aware of nitrosamine impurities in certain samples of rifampin. [61] The FDA and manufacturers are investigating the origin of these impurities in rifampin, and the agency is developing testing methods for regulators and industry to detect the 1-methyl-4-nitrosopiperazine (MNP ...
Rational Bézier curve – polynomial curve defined in homogeneous coordinates (blue) and its projection on plane – rational curve (red) In mathematics, homogeneous coordinates or projective coordinates, introduced by August Ferdinand Möbius in his 1827 work Der barycentrische Calcul, [1] [2] [3] are a system of coordinates used in projective geometry, just as Cartesian coordinates are used ...
Rifampin rapidly kills fast-dividing bacilli strains as well as "persisters" cells, which remain biologically inactive for long periods of time that allow them to evade antibiotic activity. [7] In addition, rifabutin and rifapentine have both been used against tuberculosis acquired in HIV-positive patients.
Management of tuberculosis refers to techniques and procedures utilized for treating tuberculosis (TB), or simply a treatment plan for TB.. The medical standard for active TB is a short course treatment involving a combination of isoniazid, rifampicin (also known as Rifampin), pyrazinamide, and ethambutol for the first two months.
Rifapentine in pregnant women has not been studied, but animal reproduction studies have resulted in fetal harm and were teratogenic. If rifapentine or rifampin are used in late pregnancy, coagulation should be monitored due to a possible increased risk of maternal postpartum hemorrhage and infant bleeding. [2]
Every irreducible complex algebraic curve is birational to a unique smooth projective curve, so the theory for curves is trivial. The case of surfaces was first investigated by the geometers of the Italian school around 1900; the contraction theorem of Guido Castelnuovo essentially describes the process of constructing a minimal model of any smooth projective surface.
In algebraic geometry, a Du Val singularity, also called simple surface singularity, Kleinian singularity, or rational double point, is an isolated singularity of a complex surface which is modeled on a double branched cover of the plane, with minimal resolution obtained by replacing the singular point with a tree of smooth rational curves, with intersection pattern dual to a Dynkin diagram of ...
Faltings's theorem is a result in arithmetic geometry, according to which a curve of genus greater than 1 over the field of rational numbers has only finitely many rational points. This was conjectured in 1922 by Louis Mordell , [ 1 ] and known as the Mordell conjecture until its 1983 proof by Gerd Faltings . [ 2 ]