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Outcome switching is the practice of changing the primary or secondary outcomes of a clinical trial after its initiation. An outcome is the goal of the clinical trial, such as survival after five years for cancer treatment.
Secondary endpoints are additional endpoints, preferably also pre-specified, for which the trial may not be powered. Surrogate endpoints are trial endpoints that have outcomes that substitute for a clinical endpoint, often because studying the clinical endpoint is difficult, for example using an increase in blood pressure as a surrogate for ...
Outcomes measures should be relevant to the target of the intervention (be it a single person or a target population). [2] Depending on the design of a trial, outcome measures can be either primary outcomes, in which case the trial is designed around finding an adequate study size (through proper randomization and power calculation). [1]
Secondary gain can also be a component of any disease, but is an external motivator. If a patient's disease allows them to miss work, avoid military duty, obtain financial compensation, obtain drugs , avoid a jail sentence, etc., these would be examples of a secondary gain.
The Goals, Plans, Action theory includes the following concepts: the individual has at least one of seven primary goals along with one of five secondary goals, and plans are both thoughtful and actionable. The Goals, Plans, Action theory declares that individuals knowingly act in order to accomplish a certain outcome.
For example, in a study examining the effect of post-secondary education on lifetime earnings, some extraneous variables might be gender, ethnicity, social class, genetics, intelligence, age, and so forth. A variable is extraneous only when it can be assumed (or shown) to influence the dependent variable.
Some of those who are making the trek, like Samantha Balsham, tell Yahoo Life that the effort is worth it to make sure their vote counts. At 19 years old, this presidential election is the first ...
Primary and secondary appraisals were assessed using different subscales. This study found that there is a functional relationship among appraisal and coping and the outcomes of stressful situations. There were significant positive correlations between primary appraisal and coping.