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A class of diseases, some of which may be autoimmune. Erythroblastosis fetalis: Mother's immune system attacks fetus. An immune system disorder but not autoimmune. Fibrodysplasia ossificans progressiva: Possibly an immune system disorder but not autoimmune. Gastrointestinal pemphigoid: No consistent evidence of association with autoimmunity.
An immune disorder is a dysfunction of the immune system. [1] These disorders can be characterized in several different ways: By the component(s) of the immune system affected; By whether the immune system is overactive or underactive; By whether the condition is congenital or acquired
A key difference is a malfunction of the innate immune system in autoinflammatory diseases, whereas in autoimmune diseases there is a malfunction of the adaptive immune system. [8] Symptoms of autoimmune diseases can significantly vary, primarily based on the specific type of the disease and the body part that it affects.
The complement system is part of the innate as well as the adaptive immune system; it is a group of circulating proteins that can bind pathogens and form a membrane attack complex. Complement deficiencies are the result of a lack of any of these proteins. They may predispose to infections but also to autoimmune conditions. [7]
Other potential causes he points to include immune system disorders or recurrent kidney infections. "In children, birth defects impacting urinary tract development can also result in kidney ...
The decreased ability of the immune system to clear infections in these patients may be responsible for causing autoimmunity through perpetual immune system activation. [ 14 ] One example is common variable immunodeficiency , in which multiple autoimmune diseases are seen, e.g., inflammatory bowel disease, autoimmune thrombocytopenia and ...
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