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TVOR is typically performed after ovarian hyperstimulation, where oocytes are pharmacologically stimulated to mature. When the ovarian follicles have reached a certain degree of development, induction of final oocyte maturation is performed, generally by an intramuscular or subcutaneous injection of human chorionic gonadotropin (hCG). [10]
Oocytes are immature egg cells that develop to maturity within a follicle in the ovary. Oocyte abnormalities can occur due to several factors, including premature ovarian insufficiency (POI) , other maturation abnormalities, maternal ageing, and mitochondrial abnormalities.
An ovarian follicle is a roughly spheroid cellular aggregation set found in the ovaries. It secretes hormones that influence stages of the menstrual cycle . In humans, women have approximately 200,000 to 300,000 follicles at the time of puberty , [ 1 ] [ 2 ] each with the potential to release an egg cell (ovum) at ovulation for fertilization ...
An oocyte (/ ˈ oʊ ə s aɪ t /, oöcyte, or ovocyte is a female gametocyte or germ cell involved in reproduction.In other words, it is an immature ovum, or egg cell.An oocyte is produced in a female fetus in the ovary during female gametogenesis.
During oogenesis, the oogonia become primary oocytes. Oocytes (immature ova) residing in the primordial follicle of the ovary are in a non-growing prophase arrested state, but have the capacity to undergo highly efficient homologous recombinational repair of DNA damages including double-strand breaks. [ 1 ]
Scientists still know very little about the ovaries, ... At birth, female babies have around 1 to 2 million oocytes, and roughly 1,000 immature eggs are lost each month after the first period. In ...
The antral follicle count (AFC) is the number of antral follicles, generally in both ovaries taken together if not specified otherwise. It can be determined by transvaginal ultrasonography . A low AFC is a major factor in the diagnosis of poor ovarian reserve , that is, low fertility characterized by low numbers of remaining oocytes in the ...
Oocytes residing in the primordial follicle of the ovary are in a non-growing prophase arrested state, but are capable of highly efficient homologous recombinational repair of DNA damages including double-strand breaks. [9] This capability allows genome integrity to be maintained and offspring health to be protected. [9]