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Like many chemotherapy drugs, dacarbazine may have numerous serious side effects, because it interferes with normal cell growth as well as cancer cell growth. Among the most serious possible side effects are birth defects to children conceived or carried during treatment; sterility, possibly permanent; or immune suppression (reduced ability to ...
Nausea and vomiting may be experienced as the most unpleasant side effects of cytotoxic drugs [4] and may result in patients delaying or refusing further radiotherapy [5] or chemotherapy. [6] The strategies of management or therapy of nausea and vomiting depend on the underlying causes. [7]
DES gained notoriety when it was shown to cause a rare vaginal tumor in girls and young women who had been exposed to this drug in utero.In 1971, the New England Journal of Medicine published a report showing that seven of eight girls and young women (ages 14 to 22) who had been diagnosed with vaginal clear cell adenocarcinoma had been exposed prenatally to DES. [5]
Some chemotherapy drugs are used in diseases other than cancer, such as in autoimmune disorders, [166] and noncancerous plasma cell dyscrasia. In some cases they are often used at lower doses, which means that the side effects are minimized, [166] while in other cases doses similar to ones used to treat cancer are used.
These drugs block one or more of the nerve signals that cause nausea and vomiting. During the first 24 hours after chemotherapy, the most effective approach appears to be blocking the 5-HT 3 nerve signal. [10] Approved 5-HT 3 inhibitors include dolasetron (Anzemet), granisetron (Kytril, Sancuso), and ondansetron (Zofran). Their antiemetic ...
This is a list of chemotherapeutic agents, also known as cytotoxic agents or cytostatic drugs, that are known to be of use in chemotherapy for cancer. This list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision. Each drug is listed once (at present), though it might fall in more ...
Common side effects include nausea, diarrhea, fever, rash, shortness of breath, numbness, vision changes, and feeling tired. [3] Severe side effects include brain dysfunction, low blood cell counts, and lung inflammation. [3] Use in pregnancy will likely result in harm to the fetus. [3]
[12] [25] As with all chemotherapy, adverse effects are common, and many side effects have been documented. [17] [19] Because docetaxel is a cell-cycle-specific agent, it is cytotoxic to all dividing cells in the body. [26] This includes tumour cells as well as hair follicles, bone marrow and other germ cells.