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Additive genetic effects occur where expression of more than one gene contributes to phenotype (or where alleles of a heterozygous gene both contribute), and the phenotypic expression of these gene (s) can be said to be the sum of these contributions. Non-additive effects involve dominance or epistasis, and cause outcomes that are not a sum of ...
Heritability measures the fraction of phenotype variability that can be attributed to genetic variation. This is not the same as saying that this fraction of an individual phenotype is caused by genetics. For example, it is incorrect to say that since the heritability of personality traits is about 0.6, that means that 60% of your personality ...
G1, G2, and G3 are different genes that contribute to phenotypic traits P1, P2, and P3. Pleiotropy (from Greek πλείων pleion, 'more', and τρόπος tropos, 'way') occurs when one gene influences two or more seemingly unrelated phenotypic traits. Such a gene that exhibits multiple phenotypic expression is called a pleiotropic gene.
Gene–environment interaction. Gene–environment interaction (or genotype–environment interaction or G×E) is when two different genotypes respond to environmental variation in different ways. A norm of reaction is a graph that shows the relationship between genes and environmental factors when phenotypic differences are continuous. [1]
Some SNPs have relatively small effect on diseases or clinical phenotypes or traits. To estimate study power, the genetic model for disease needs to be considered, such as dominant, recessive, or additive effects. Due to genetic heterogeneity, GWAS analysis must be adjusted for race.
Polygene. A polygene is a member of a group of non- epistatic genes that interact additively to influence a phenotypic trait, thus contributing to multiple-gene inheritance (polygenic inheritance, multigenic inheritance, quantitative inheritance[1]), a type of non-Mendelian inheritance, as opposed to single-gene inheritance, which is the core ...
Genetic correlation. In multivariate quantitative genetics, a genetic correlation (denoted or ) is the proportion of variance that two traits share due to genetic causes, [1][2][3] the correlation between the genetic influences on a trait and the genetic influences on a different trait [4][5][6][7][8][9] estimating the degree of pleiotropy or ...
Genetic variance has three major components: the additive genetic variance, dominance variance, and epistatic variance. [3] Additive genetic variance involves the inheritance of a particular allele from your parent and this allele's independent effect on the specific phenotype, which will cause the phenotype deviation from the mean phenotype.