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Oxidation of cytoplasmic NADH by the cytosolic form of the enzyme creates glycerol-3-phosphate from dihydroxyacetone phosphate. Once the glycerol-3-phosphate has moved through the outer mitochondrial membrane it can then be oxidised by a separate isoform of glycerol-3-phosphate dehydrogenase that uses quinone as an oxidant and FAD as a co ...
14555 Ensembl ENSG00000167588 ENSMUSG00000023019 UniProt P21695 P13707 RefSeq (mRNA) NM_005276 NM_001257199 NM_010271 RefSeq (protein) NP_001244128 NP_005267 NP_034401 Location (UCSC) Chr 12: 50.1 – 50.11 Mb Chr 15: 99.62 – 99.62 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glycerol-3-phosphate dehydrogenase 1 is an enzyme that is encoded by the GPD1 gene in humans. Function ...
The glycerol phosphate shuttle was first characterized as a major route of mitochondrial hydride transport in the flight muscles of blow flies. [5] [6] It was initially believed that the system would be inactive in mammals due to the predominance of lactate dehydrogenase activity over glycerol-3-phosphate dehydrogenase 1 (GPD1) [5] [7] until high GPD1 and GPD2 activity were demonstrated in ...
The 3 substrates of this enzyme are sn-glycerol 3-phosphate, NAD +, and NADP +, whereas its 4 products are glycerone phosphate, NADH, NADPH, and H +. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD + or NADP + as acceptor. The systematic name of this enzyme class is sn ...
Glycerol 3-phosphate is synthesized by reducing dihydroxyacetone phosphate (DHAP), an intermediate in glycolysis. The reduction is catalyzed by glycerol-3-phosphate dehydrogenase. DHAP and thus glycerol 3-phosphate can also be synthesized from amino acids and citric acid cycle intermediates via the glyceroneogenesis pathway. + NAD(P)H + H + → ...
Triglycerides are built from three fatty acids, esterified onto each of three hydroxy groups of glycerol, which is derived from glycerol 3-phosphate.In mammals, glycerol 3-phosphate is usually synthesized through glycolysis, a metabolic pathway that degrades glucose into fructose 1,6-bisphosphate and then into two molecules of dihydroxyacetone phosphate, which beget glycerol 3-phosphate and ...
In enzymology, a glycerol-3-phosphate dehydrogenase (NAD +) (EC 1.1.1.8) is an enzyme that catalyzes the chemical reaction. sn-glycerol 3-phosphate + NAD + glycerone phosphate + NADH + H + The two substrates of this enzyme are sn-glycerol 3-phosphate and NAD +, whereas its 3 products are glycerone phosphate, NADH, and H +.
Identifiers; EC no. 1.1.5.3: CAS no. 9001-49-4 : Alt. names: valpha-glycerophosphate dehydrogenase, alpha-glycerophosphate dehydrogenase (acceptor), anaerobic glycerol-3-phosphate dehydrogenase, DL-glycerol 3-phosphate oxidase (misleading), FAD-dependent glycerol-3-phosphate dehydrogenase, FAD-dependent sn-glycerol-3-phosphate dehydrogenase, FAD-GPDH, FAD-linked glycerol 3-phosphate ...