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Laryngeal cancer may spread by: direct extension to adjacent structures, metastasis to regional cervical lymph nodes, or via the blood stream. The most common site of distant metastases is the lung. Laryngeal cancer occurred in 177,000 people in 2018, and resulted in 94,800 deaths (an increase from 76,000 deaths in 1990).
Laryngeal cancer begins in the larynx, or "voice box", and is the second most common type of head and neck cancer encountered. [5] Cancer may occur on the vocal folds themselves ("glottic" cancer) or on tissues above and below the true cords ("supraglottic" and "subglottic" cancers, respectively).
Hinni M, Salassa J, Grant D, Pearson B, Hayden R, Martin A, Christiansen H, Haughey B, Nussenbaum B, Steiner W, Transoral Laser Microsurgery for Advanced Laryngeal Cancer, Archives of Otolaryngology–Head & Neck Surgery, Volume 133, No 12, pp 1198–1204, December 2007.
HPV+OPC presents in one of four ways: as an asymptomatic abnormality in the mouth found by the patient or a health professional such as a dentist; with local symptoms such as pain or infection at the site of the tumor; with difficulties of speech, swallowing, and/or breathing; or as a swelling in the neck (if the cancer has spread to lymph nodes).
In fact, 97 percent of patients diagnosed with Reinke's edema are habitual smokers. Other identified risk factors include overuse of the vocal cords, gastroesophageal reflux, and hypothyroidism. [7] The disease is more often cited in women than in men, because lower voice changes are more noticeable in women. [2] [4] [7]
An electrolarynx, sometimes referred to as a "throat back", is a medical device used to produce clearer speech by those people who have lost their voice box, usually due to cancer of the larynx.
A common symptom of laryngeal papillomatosis is a change in voice quality. More specifically, hoarseness is observed. [4] [5] As a consequence of the narrowing of the laryngeal or tracheal parts of the airway, shortness of breath, chronic cough and stridor (i.e. noisy breathing which can sound like a whistle or a snore), can be present.
The stage at which the cancer presents itself affects the type of definitive treatment, chance of cure, recurrence of cancer and survival rate of the patient. Generally the patient presents very late due to the lack of definitive symptoms in the early stages of the disease. Nearly three fourths of the patients present in Stage III or later. [22]