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In bioinformatics, BLAST (basic local alignment search tool) [3] is an algorithm and program for comparing primary biological sequence information, such as the amino-acid sequences of proteins or the nucleotides of DNA and/or RNA sequences.
Lipman is very well known for his seminal work on a series of sequence similarity algorithms, starting from the Wilbur-Lipman [13] algorithm in 1983, FASTA search [14] [15] in 1985, BLAST [16] in 1990, and Gapped BLAST and PSI-BLAST [17] in 1997. BLAST eventually became the most widely-used and highly-cited (over 160,000 citations as of 2021 ...
Stephen Frank Altschul (born February 28, 1957) is an American mathematician who has designed algorithms that are used in the field of bioinformatics (the Karlin–Altschul algorithm [2] and its successors [3]). Altschul is the co-author of the BLAST algorithm used for sequence analysis of proteins and nucleotides. [4] [5]
A more complete list of available software categorized by algorithm and alignment type is available at sequence alignment software, but common software tools used for general sequence alignment tasks include ClustalW2 [45] and T-coffee [46] for alignment, and BLAST [47] and FASTA3x [48] for database searching.
BLAST is an algorithm used for calculating sequence similarity between biological sequences, such as nucleotide sequences of DNA and amino acid sequences of proteins. [7] BLAST is a powerful tool for finding sequences similar to the query sequence within the same organism or in different organisms.
Later, the BLAST algorithm was developed for performing fast, optimized searches of gene sequence databases. BLAST and its derivatives are probably the most widely used algorithms for this purpose. [4] The emergence of the phrase "computational genomics" coincides with the availability of complete sequenced genomes in the mid-to-late 1990s.
As an option to WU-BLAST, Gish implemented a faster, more memory-efficient and more sensitive two-hit BLAST algorithm than was used by the NCBI software for many years. In 1999, Gish added support to WU-BLAST for the Extended Database Format (XDF), the first BLAST database format capable of accurately representing the entire draft sequence of ...
BLAST [5] is an algorithm for comparing biomacromolecule primary structure, most often nucleotide sequence of DNA/RN, and amino acid sequence of proteins, stored in the bioinformatic databases, with the query sequence. The algorithm uses scoring of the available sequences against the query by a scoring matrix such as BLOSUM 62. The highest ...