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Gas chromatography (GC) is a common type of chromatography used in analytical chemistry for separating and analyzing compounds that can be vaporized without decomposition. Typical uses of GC include testing the purity of a particular substance, or separating the different components of a mixture. [ 1 ]
Similar to the process of distillation, gas-liquid chromatography (typically referred to as gas chromatography, or, more simply, GC) utilises a distillation tower to separate the petroleum. However, compared to distillation's 2 to 300 theoretical plates, gas chromatography includes more than 25,000. This provides a greater degree of separation ...
Pyrolysis–gas chromatography–mass spectrometry is a method of chemical analysis in which the sample is heated to decomposition to produce smaller molecules that are separated by gas chromatography and detected using mass spectrometry. Pyrolysis is the thermal decomposition of materials in an inert atmosphere or a vacuum.
The mass spectrometry process normally requires a very pure sample while gas chromatography using a traditional detector (e.g. Flame ionization detector) cannot differentiate between multiple molecules that happen to take the same amount of time to travel through the column (i.e. have the same retention time), which results in two or more ...
Others introduced mass spectrometers to gas chromatography in the late 1950s. [29] The work of Martin and Synge also set the stage for high performance liquid chromatography, suggesting that small sorbent particles and pressure could produce fast liquid chromatography techniques. This became widely practical by the late 1960s (and the method ...
The use of a mass spectrometer as the detector in gas chromatography was developed during the 1950s by Roland Gohlke and Fred McLafferty. [ 13 ] [ 14 ] [ 15 ] The development of affordable and miniaturized computers has helped in the simplification of the use of this instrument, as well as allowed great improvements in the amount of time it ...
Gas chromatography (GC) coupled to mass spectrometry (MS) is one of the most widespread routine technologies applied to the large scale screening and discovery of novel biomarkers in metabolomics. However, the majority of MSTs currently measured in plant metabolomic profiling experiments remains unidentified due to the lack of authenticated ...
John Knox was an early leader in the field of gas chromatography. As a PhD student in at Pembroke College, Cambridge, [3] in 1953 Knox, together with his fellow student Howard Purnell, constructed a self-designed gas chromatographer in their lab and used this to pioneer early research in the field. In later experiments Knox was the first to use ...