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[1] [8] Faricimab is the first bispecific monoclonal antibody [9] to target both vascular endothelial growth factor (VEGF) [1] and angiopoietin 2 (Ang-2). [1] By targeting these pathways, faricimab stabilizes blood vessels in the retina. [9] It is given by intravitreal injection (injection into the eye) by an ophthalmologist. [1]
According to a 2012 report by Sun Life Financial the average cost of specialty drug claims was $10,753 versus $185 for non-specialty drugs and the cost of specialty drugs continues to rise. With such steep prices by 2012 specialty drugs represented 15-20% of prescription drug reimbursement claims. [60]
Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). [12] It has also been given topically (on the skin) for actinic keratoses, skin cancers and Bowen's disease [12] (a type of cutaneous squamous-cell carcinoma), and as eye drops for treatment of ocular surface squamous neoplasia. [13]
Natalizumab, sold under the brand name Tysabri among others, is a medication used to treat multiple sclerosis and Crohn's disease. [9] It is a humanized monoclonal antibody against the cell adhesion molecule α4-integrin. [9]
Varenicline, sold under the brand names Chantix and Champix among others, is a medication used for smoking cessation [5] [7] and for the treatment of dry eye syndrome. [6] [8] It is a nicotinic acetylcholine receptor partial agonist.
A medical professional applies nose drops. Nasal administration, popularly known as snorting, is a route of administration in which drugs are insufflated through the nose.It can be a form of either topical administration or systemic administration, as the drugs thus locally delivered can go on to have either purely local or systemic effects.
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