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Glucose 6-phosphatase-β is a ubiquitously expressed, 346-amino acid membrane protein that shares 36% sequence identity with glucose 6-phosphatase-α. Within the glucose 6-phosphatase-β enzyme, sequence alignments predict that its active site contains His167, His114, and Arg79.
Glucose-6-phosphatase, catalytic subunit (glucose 6-phosphatase alpha) is an enzyme that in humans is encoded by the G6PC gene. [ 5 ] [ 6 ] Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate.
This gene encodes the catalytic subunit of glucose 6-phosphatase (G6Pase). G6Pase is located in the endoplasmic reticulum (ER) and catalyzes the hydrolysis of glucose 6-phosphate to glucose and phosphate in the last step of the gluconeogenic and glycogenolytic pathways. [5]
14378 Ensembl ENSG00000278373 ENSG00000152254 ENSMUSG00000005232 UniProt Q9NQR9 Q9Z186 RefSeq (mRNA) NM_001081686 NM_021176 NM_001289856 NM_001289857 NM_021331 RefSeq (protein) NP_001075155 NP_066999 NP_001276785 NP_001276786 NP_067306 Location (UCSC) Chr 2: 168.9 – 168.91 Mb Chr 2: 69.04 – 69.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glucose-6-phosphatase 2 is an enzyme ...
This reaction converts glucose 6-phosphate to fructose 6-phosphate in preparation for phosphorylation to fructose 1,6-bisphosphate. [2] The addition of the second phosphoryl group to produce fructose 1,6-bisphosphate is an irreversible step, and so is used to irreversibly target the glucose 6-phosphate breakdown to provide energy for ATP ...
d -Glucose + 2 [NAD] + + 2 [ADP] + 2 [P] i 2 × Pyruvate 2 × + 2 [NADH] + 2 H + + 2 [ATP] + 2 H 2 O Glycolysis pathway overview The use of symbols in this equation makes it appear unbalanced with respect to oxygen atoms, hydrogen atoms, and charges. Atom balance is maintained by the two phosphate (P i) groups: Each exists in the form of a hydrogen phosphate anion, dissociating to contribute ...
Glucose-6-phosphate translocase is a transmembrane protein providing a selective channel between the endoplasmic reticulum lumen and the cytosol.The enzyme is made up of three separate transporting subunits referred to as G6PT1 (subunit 1), G6PT2 (subunit 2) and G6PT3 (subunit 3).
English: glucose-6-phosphatase system: in the end of the gluconeogenesis glc-6-p is transported into the ER (G6PT = T1) and dephosphorylated (G6Pase). Glucose is transported out of the cell passing two glucose-transporters (GLUT7 = T3 and GLUT2). Inorg. Phosphate is transported back to the cytosol by the T2 transporter