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As of August 2021, an FDA-approved medication exists for IH called Xywav, which is an oral solution of calcium, magnesium, potassium, and sodium oxybates; [5] in addition to several off-label treatments (primarily FDA-approved narcolepsy medications). [6] Idiopathic hypersomnia may also be referred to as IH, IHS, or primary hypersomnia, [7] and ...
Xywav is a medication used to treat cataplexy or excessive daytime sleepiness. [2] [3] It contains a mixture of the oxybate salts calcium oxybate, magnesium oxybate, potassium oxybate, and sodium oxybate. [2] It is a central nervous system (CNS) depressant and it is taken by mouth. [2]
Many medications can lead to secondary hypersomnia. Therefore, a patient's complete medication list should be carefully reviewed for sleepiness or fatigue as side effects. In these cases, careful withdrawal from the possibly offending medication(s) is needed; then, medication substitution can be undertaken. [8]
Clarithromycin has been researched as a potential treatment for idiopathic hypersomnia (IH) in adults, but the evidence is limited. A 2021 Cochrane study determined that the evidence is inadequate to definitively determine the efficacy of clarithromycin in the management of idiopathic hypersomnia. [ 10 ]
Another underlying sleep disorder, such as narcolepsy, sleep apnea, [8] idiopathic hypersomnia, or restless legs syndrome; Disorders such as clinical depression or atypical depression [medical citation needed] Tumors, head trauma, anemia, kidney failure, hypothyroidism, or an injury to the central nervous system [9] Drug abuse [medical citation ...
In order to help further determine whether clarithromycin is truly beneficial for the treatment of narcolepsy and idiopathic hypersomnia, a small, double-blind, randomized, controlled clinical trial was completed in 2012. [77] "In this pilot study, clarithromycin improved subjective sleepiness in GABA-related hypersomnia.
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