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Goblet cells are simple columnar epithelial cells, having a height of four times that of their width. The cytoplasm of goblet cells tends to be displaced toward the basal end of the cell body by the large mucin granules, which accumulate near the apical surface of the cell along the Golgi apparatus, which lies between the granules and the nucleus.
The Ii antigen system is a human blood group system based upon a gene on chromosome 6 and consisting of the I antigen and the i antigen. [1] The I antigen is normally present on the cell membrane of red blood cells in all adults, while the i antigen is present in fetuses and newborns. [2]
HAVCR2 was first described in 2002 as a cell surface molecule expressed on IFNγ producing CD4+ Th1 and CD8+ Tc1 cells. [5] [6] Later, the expression was detected in Th17 cells, [7] regulatory T-cells, [8] and innate immune cells (dendritic cells, NK cells, monocytes, macrophages). [9] [10] HAVCR2 receptor is a regulator of the immune response.
The discussion that follows now concerns alpha/beta T cells. The TCR (of αβ T-cells) binds a bimolecular complex displayed at the surface of some other cells called an antigen-presenting cell (APC). This complex consists of: a fragment of an antigen lying within the groove of a histocompatibility molecule. The complex has been compared to a ...
HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene. [5] [6] The invariant chain (Abbreviated Ii) is a polypeptide which plays a critical role in antigen presentation.
In most eukaryotes, a cell carries two versions of each gene, each referred to as an allele. Each parent passes on one allele to each offspring. An individual gamete inherits a complete haploid complement of alleles on chromosomes that are independently selected from each pair of chromatids lined up on the metaphase plate. Without recombination ...
Immunolabeling - Antigen Detection of Tissue via Tagged Antigen-specific Antibody. Immunolabeling is a biochemical process that enables the detection and localization of an antigen to a particular site within a cell, tissue, or organ. Antigens are organic molecules, usually proteins, capable of binding to an antibody.
HLA-DM (human leukocyte antigen DM) is an intracellular protein involved in the mechanism of antigen presentation on antigen presenting cells (APCs) of the immune system. [2] It does this by assisting in peptide loading of major histocompatibility complex (MHC) class II membrane-bound proteins. [3] HLA-DM is encoded by the genes HLA-DMA and HLA ...