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Prostaglandin E 2 receptor 4 (EP 4) is a prostaglandin receptor for prostaglandin E2 (PGE 2) encoded by the PTGER4 gene in humans. [5] It is one of four identified EP receptors, the others being EP 1, EP 2, and EP 3, all of which bind with and mediate cellular responses to PGE 2 and also, but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin ...