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Allergen immunotherapy, also known as desensitization or hypo-sensitization, is a medical treatment for environmental allergies (such as insect bites) and asthma. [ 1 ] [ 2 ] Immunotherapy involves exposing people to larger and larger amounts of allergens in an attempt to change the immune system's response.
The treatment uses dilutions of allergen and enzyme to which T-regulatory lymphocytes are believed to respond by favouring desensitization, or down-regulation, rather than sensitization. Once activated these lymphocytes travel to lymph nodes and reproduce or stimulate similar T-lymphocytes.
In medicine, desensitization is a method to reduce or eliminate an organism's negative reaction to a substance or stimulus. In pharmacology , drug desensitization refers to two related concepts. First, desensitization may be equivalent to drug tolerance and refers to subjects' reactions (positive or negative) to a drug reducing following its ...
Immunotherapy involves exposing people to larger and larger amounts of allergen in an effort to change the immune system's response. [ 6 ] Meta-analyses have found that injections of allergens under the skin is effective in the treatment in allergic rhinitis in children [ 135 ] [ 136 ] and in asthma. [ 134 ]
Curex is an American telehealth company specializing in immunology, specifically the diagnosis and treatment of allergies, including the prescription and delivery of allergy immunotherapy. [1] The company was founded by Gene Kakaulin and Charles Jacoby in 2020 [ 2 ] and is headquartered in New York City. [ 3 ]
Dupilumab is indicated for the treatment of moderate-to-severe atopic dermatitis, moderate-to-severe asthma, and for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP). [ 4 ] [ 5 ] [ 15 ] [ 16 ] [ 9 ] It has been shown to be effective at treating aspirin-exacerbated respiratory disease (AERD), a typically difficult to treat ...
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