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Alzheimer's disease is the most common form of dementia, accounting for 60% of all cases, and is the sixth leading cause of death in the elderly. [ 11 ] [ 12 ] The disease typically presents itself with intracellular aggregation of hyper-phosphorylated tau, forming neurofibrillary tangles (NFTs) , and the extracellular aggregation of amyloid ...
An estimated 6.5 million Americans age 65 and up are living with Alzheimer's disease. The progressive disease is devastating and can cause symptoms ranging from memory loss to seizures, according ...
Regarding incidence, cohort longitudinal studies (studies where a disease-free population is followed over the years) provide rates between 10 and 15 per thousand person-years for all dementias and 5–8 for AD, [236] [237] which means that half of new dementia cases each year are Alzheimer's disease. Advancing age is a primary risk factor for ...
Further research into molecules like miR-212-3p might shed new light on potential therapeutic approaches for Alzheimer's disease, possibly alongside interventions targeted at APP. [21] [22] This type accounts for no more than 10–15% of EOFAD. [medical citation needed] As of 2023, the count of known pathogenic APP mutations stands at just over ...
Therefore, early and accurate diagnosis of dementia and staging can be essential to proper clinical care. Without the ability to reliably assess dementia across the board, the misuse of anti-dementia compounds could have negative consequences, such as patients receiving the wrong medication, or not receiving treatment in the early stages of ...
In 1999, a DSM-5 Research Planning Conference, sponsored jointly by APA and the National Institute of Mental Health (NIMH), was held to set the research priorities. Research Planning Work Groups produced "white papers" on the research needed to inform and shape the DSM-5 [ 42 ] and the resulting work and recommendations were reported in an APA ...