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Triiodothyronine, also known as T 3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate. [1] Production of T 3 and its prohormone thyroxine (T 4) is activated by thyroid-stimulating hormone (TSH
Plasma T 3 concentrations in this population are decreased by 25% to 40%. [10] TSH must be routinely monitored since there is a risk of coronary artery disease, hyperthyroidism and excessive bone loss from inadequate or abnormal thyroid replacement. [10]
Desiccated Thyroid became a commercial treatment option in 1934 with Westhroid, [citation needed]. In the early 1960s, desiccated thyroid hormones (thyroid extract) began to be replaced by levothyroxine (synthetic T4), or by combinations of T4 and T3. Replacement occurred faster in the United Kingdom than in North America, but by the 1980s more ...
The T4 → T3 conversion is mediated by the selenoenzyme iodothyronine deiodinase. T3-thyroxine is a unique example of an iodine compound that is essential for human health. [38] [39] T 3 binds to thyroid receptor proteins in the cell nucleus and causes metabolic effects through the control of DNA transcription and protein synthesis. [24]
The thyroid system of the thyroid hormones T 3 and T 4 [1] Thyroid hormones are two hormones produced and released by the thyroid gland, triiodothyronine (T 3) and thyroxine (T 4). They are tyrosine-based hormones that are primarily responsible for regulation of metabolism. T 3 and T 4 are partially composed of iodine, derived from food. [2]
It is the primary form of thyroid hormone found in the blood and acts as a prohormone of the more active thyroid hormone, triiodothyronine (T 3). [1] Thyroxine and its active metabolites are essential for regulating metabolic rate , supporting heart and muscle function , promoting brain development , and maintaining bone health .
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