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Glioblastoma (GBM) is the most common and aggressive malignant brain tumor, accounting for about 15% of all primary malignant brain tumors.
Surgery is the first stage of treatment of glioblastoma. An average GBM tumor contains 10 11 cells, which is on average reduced to 10 9 cells after surgery (a reduction of 99%). Benefits of surgery include resection for a pathological diagnosis, alleviation of symptoms related to mass effect, and potentially removing disease before secondary ...
Temozolomide is an alkylating agent used to treat serious brain cancers; most commonly as second-line treatments for astrocytoma and as the first-line treatment for glioblastoma. [ 4 ] [ 6 ] [ 7 ] Olaparib in combination with temozolomide demonstrated substantial clinical activity in relapsed small cell lung cancer . [ 8 ]
All treatments for CNS tumors have significant risks and side-effects. In cases where tumors are slow growing and do not cause symptoms, it may be preferable to closely watch the patient's condition without any treatment, until new test results or symptoms indicate that the patient's condition has worsened. [17]
The decision to prescribe this treatment is based on a patient's overall health, type of tumor, and extent of cancer. The toxicity and many side effects of the drugs, and the uncertain outcome of chemotherapy in brain tumors puts this treatment further down the line of treatment options with surgery and radiation therapy preferred. [79]
Astrocytomas: astrocytes (glioblastoma multiforme is a malignant astrocytoma and the most common primary brain tumor among adults). Oligodendrogliomas: oligodendrocytes; Brainstem glioma: develop in the brain stem; Optic nerve glioma: develop in or around the optic nerve; Chordoid glioma, a rare low-grade tumor of the third ventricle [54]
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