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The FDA recommends HRT to be avoided in women with a history or risk of breast cancer, undiagnosed genital bleeding, untreated high blood pressure, unexplained blood clots, or liver disease. [28] HRT for the vasomotor symptoms of hypoestrogenism include different forms of estrogen, such as conjugated equine estrogens, 17β-estradiol ...
Women with vasomotor symptoms during menopause seem to have an especially unfavorable cardiometabolic profile, [36] as well as women with premature onset of menopause (before 45 years of age). [37] These risks can be reduced by managing risk factors, such as tobacco smoking, hypertension, increased blood lipids and body weight. [38] [39]
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Menopause is a natural decline in the ovarian function of women who reach the age between 45 and 54 years. "About 25 million women pass through menopause worldwide each year, and it has been estimated that, by the year 2030, the world population of menopausal and postmenopausal women will be 1.2 billion, with 47 million new entrants each year."
Research on hot flashes is mostly focused on treatment options. The exact cause and pathogenesis, or causes, of vasomotor symptoms (VMS)—the clinical name for hot flashes—has not yet been fully studied. [11] [12] Hot flashes are associated with declining levels of estrogen (estrogen withdrawal) and other hormonal changes. [13]
Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. [ 1 ] [ 2 ] Effects of menopause can include symptoms such as hot flashes , accelerated skin aging, vaginal dryness , decreased muscle mass , and ...
That typically stems from the 2002 Women’s Health Initiative study, which reported that HRT causes an increased risk of heart disease, breast cancer and stroke, and had more risks than benefits.
After menopause the vaginal epithelium changes and becomes a few layers thick. [18] Many of the signs and symptoms that accompany menopause occur in atrophic vaginitis. [3] The earliest symptoms of atrophic vaginitis may be decreased vaginal lubrication, while other symptoms may appear later. [14] Genitourinary symptoms include dryness [3] [19 ...