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Maropitant (INN; [3] brand name: Cerenia, used as maropitant citrate (), is a neurokinin-1 (NK 1) receptor antagonist developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs.
Drug administration via the nasal cavity yields rapid drug absorption and therapeutic effects. [33] This is because drug absorption through the nasal passages does not go through the gut before entering capillaries situated at tissue cells and then systemic circulation and such absorption route allows transport of drugs into the central nervous ...
The duration of estradiol esters in oil solution by intramuscular injection is dose-dependent. [282] With estradiol valerate, it is reported that a dose of 5 mg has a duration of 7 to 8 days, [ 274 ] 10 mg a duration of 10 to 14 days, [ 265 ] [ 282 ] 40 mg a duration of 2 to 3 weeks, and 100 mg a duration of 3 to 4 weeks. [ 282 ]
Dosage [b] Estradiol: Various: Estrogen: Oral: 2–10 mg/day Various: Estrogen: Sublingual: 1–8 mg/day Climara [c] Estrogen: TD patch: 25–400 μg/day Divigel [c ...
Side effects of estradiol valerate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [15] [13] [14] Estradiol valerate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [5] [4] [16] It is an estrogen ester and a prodrug of estradiol in the body.
Examples of such side effects include breast tenderness and enlargement, nausea, bloating, edema, headache, and melasma. [16] The combination of estradiol enantate and DHPA as a combined injectable contraceptive has shown no adverse effects on liver function, lipid metabolism, or coagulation. [38] [2]
Estradiol cypionate is usually used at a dosage of 1 to 5 mg by intramuscular injection every 3 to 4 weeks in the treatment of menopausal symptoms such as hot flashes and vaginal atrophy, at a dosage of 1.5 to 2 mg by intramuscular injection once a month in the treatment of female hypoestrogenism due to hypogonadism, and at a dosage of 2 to 10 ...
Situations that may require an authority include where the drug may only have benefit in limited conditions, the true cost of the drug is high, or when there is a risk of dependence. Some states have subsets of Schedule 4 with additional requirements (see below). Schedule 4 medicines cannot be advertised directly to the public. Examples:
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