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NC should therefore be distinguished from vascular claudication, which stems from a circulatory problem rather than a neural one. The term neurogenic claudication is sometimes used interchangeably with spinal stenosis. However, the former is a clinical term, while the latter more specifically describes the condition of spinal narrowing. [4]
Spinal stenosis is an abnormal narrowing of the spinal canal or neural foramen that results in pressure on the spinal cord or nerve roots. [6] Symptoms may include pain, numbness, or weakness in the arms or legs. [1] Symptoms are typically gradual in onset and improve with leaning forward. [1]
Forward displacement of a proximal vertebra in relation to its adjacent vertebra in association with an intact neural arch, and in the presence of degenerative changes, is known as degenerative spondylolisthesis, [9] [10] which narrows the spinal canal, and symptoms of spinal stenosis are common. Of these, neural claudication is most common.
Cervical canal stenosis may lead to serious symptoms such as major body weakness and paralysis. Such severe spinal stenosis symptoms are virtually absent in lumbar stenosis, however, as the spinal cord terminates at the top end of the adult lumbar spine, with only nerve roots (cauda equina) continuing further down. [3]
Narrow aqueducts have no unusual tissue characteristics, and ventricles are lined with normal epithelial cells. Narrowing can be a defect from birth that results in congenital aqueductal stenosis. Developmental errors that could result in this defect include abnormal folding of the neural plate which causes the neural tube to be narrowed from ...
An upper motor neuron lesion (also known as pyramidal insufficiency) Is an injury or abnormality that occurs in the neural pathway above the anterior horn cell of the spinal cord or motor nuclei of the cranial nerves.
This medical treatment is usually accompanied by physiotherapy to increase back and stomach muscles. Thus, the spine can be both relieved and stabilized. [ 10 ] If these conservative measures do not bring about betterment, minimally invasive procedures such as a facet infiltration can be conducted to offer relief.
These disruptions may allow axons to penetrate the vacated space and permit restoration of neural plasticity. Perineuronal nets (PNNs) are specialized extracellular matrix structures responsible for synaptic stabilization in the adult brain. [1] PNNs are found around certain neuron cell bodies and proximal neurites in the central nervous system.