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Fel d 1 is a secretoglobin protein complex that, in cats, is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes. [2] [3] Among cats, Fel d 1 is produced largely in their saliva and by the sebaceous glands located in their skin. It is the primary allergen present on cats and kittens.
Fel d 1 is the most prominent cat allergen, accounting for 96% of human cat allergies. [4] The remaining cat allergens are Fel d 2–8, [5] with Fel d 4, a major urinary protein found in the saliva of cats, [6] occurring the most in humans among the other seven allergens. All cats produce Fel d 1, including hypoallergenic cats.
Most human cat allergies are caused by Fel d 1.Allerca (and earlier, Geneticas) scientists tried to delete or disable the gene. The company now says it has "discovered" a breed of cats that had a mutant version of the protein that did not induce an allergic response.
Fel d 1 was supposed to be put into two subfamilies: chain 1 in subfamily 4, and chain 2 in subfamily 5. [3] Although it is not mentioned in the 2011 update, InterPro matches suggest that CH1 is similar to 1B and CH2 is similar to 2B. [5] Extra computational research confirms the similarity, invalidating subfamilies 4 and 5 fully. [6]
The post 8 Hypoallergenic Cats for People with Allergies appeared first on Reader's Digest. These breeds may be the answer to your problems. 8 Hypoallergenic Cats for People with Allergies
Many people believe that the breed produces less Fel d 1, the primary allergen present in cats. [58] In 1999, Indoor Biotechnologies tested the fur of four cats for Fel d 1; a mixed breed, two Siberians, and an Abyssinian. [59] The results showed the Siberian and Abyssinian cat fur as having lower Fel d 1 levels than the mixed breed cat. [59]