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Primary CNS lymphoma is highly associated with Epstein-Barr virus (EBV) infection (> 90%) in immunodeficient patients (such as those with AIDS and those immunosuppressed), [4] and does not have a predilection for any particular age group. Mean CD4+ count at time of diagnosis is ~50/μL. In immunocompromised patients, prognosis is usually poor.
The Central Nervous System – International Prognostic Index (CNS-IPI) has emerged as a valuable tool for risk stratification. Developed by the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL) in 2016, the CNS-IPI integrates factors from the International Prognostic Index (IPI) along with additional considerations such as kidney and ...
Primary central nervous system lymphoma occurs most often in immunocompromised patients, in particular those with AIDS, but it can occur in the immunocompetent, as well. It has a poor prognosis, particularly in those with AIDS. Treatment can consist of corticosteroids, radiotherapy, and chemotherapy, often with methotrexate.
Previous to IPI's development, the primary consideration in assessing prognosis was the Ann Arbor stage alone, but this was increasingly found to be an inadequate means of predicting survival outcomes, and so other factors were studied. [citation needed] In 1984, the first prognostic indicator for advanced non-Hodkin's lymphoma was developed.
Diffuse large B-cell lymphoma (DLBCL) is a cancer of B cells, a type of lymphocyte that is responsible for producing antibodies.It is the most common form of non-Hodgkin lymphoma among adults, [1] with an annual incidence of 7–8 cases per 100,000 people per year in the US and UK.
Aggressive lymphoma, also known as high-grade lymphoma, is a group of fast growing non-Hodgkin lymphoma. [1]There are several subtypes of aggressive lymphoma. These include AIDS-associated lymphoma, angioimmunoblastic lymphoma, Burkitt lymphoma, central nervous system (CNS) lymphoma, diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL) and peripheral T-cell lymphoma. [1]