Ads
related to: where is her2 found genetically related- Side Effects Information
View Patient Side Effects Info For
A HER2+ mBC Treatment.
- Financial Assistance Info
Access Financial Support Info For
HER2+ Metastatic Breast Cancer.
- Patient Resources
Find Patient & Care Partner Info
For A HER2+ mBC Treatment.
- Sign Up For Information
Patients & Care Partners - Sign Up
For Helpful Information.
- Downloadable Resources
Find Downloadable Resources For
Patients & Care Partners.
- Clinical Study Results
View Info On Clinical Data For A
HER2+ mBC Treatment. Patient Site.
- Side Effects Information
Search results
Results From The WOW.Com Content Network
HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. Neu is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor. ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR.
The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member. In humans, the family includes Her1 (EGFR, ErbB1), Her2 , Her3 , and Her4 . The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are ...
HER2 is overexpressed in 20-30% of breast cancers and is commonly associated with poor prognosis. It is therefore an oncogene whose differently spliced variants have been shown to have different functions.
The HER2 gene (also known as HER2/neu and ErbB2 gene) is amplified in 20–30% of early-stage breast cancers. [44] Trastuzumab is a monoclonal antibody targeting HER2, inducing an immune-mediated response that causes internalization and recycling of HER2. It may also upregulate cell cycle inhibitors such as p21 Waf1 and p27 Kip1. [58]
Triple-negative means the cancer does not have estrogen or progesterone receptors and lacks or has very little of the HER2 protein, the organization notes. This cancer has fewer therapies than ...
Cancer is a genetic disease where changes to genes can cause cells to grow and divide out of control. Each cancer can have a unique combination of genetic mutations, and even cells within the same tumour may have different genetic changes. In clinical settings, it has commonly been observed that the same types and doses of treatment can result ...
Ads
related to: where is her2 found genetically related