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Benznidazole is a nitroimidazole antiparasitic with good activity against acute infection with Trypanosoma cruzi, commonly referred to as Chagas disease. [14] Like other nitroimidazoles, benznidazole's main mechanism of action is to generate radical species which can damage the parasite's DNA or cellular machinery. [17]
Chagas disease is managed using antiparasitic drugs to eliminate T. cruzi from the body, and symptomatic treatment to address the effects of the infection. [6] As of 2018, benznidazole and nifurtimox were the antiparasitic drugs of choice for treating Chagas disease, [2] though benznidazole is the only drug available in most of Latin America. [40]
Nifurtimox, sold under the brand name Lampit, is a medication used to treat Chagas disease and sleeping sickness. [2] [4] For sleeping sickness it is used together with eflornithine in nifurtimox-eflornithine combination treatment. [4] In Chagas disease it is a second-line option to benznidazole. [5] It is given by mouth. [2]
Doctors, researchers, and patient advocates say the U.S. could be doing far more to combat Chagas, which causes serious heart disease in an estimated 30% of infected people and can also lead to ...
Doctors, researchers, and patient advocates say the U.S. could be doing far more to combat Chagas, which causes serious heart disease in an estimated 30% of infected people and can also lead to ...
The logo of the Drugs for Neglected Diseases initiative (DNDi) The Drugs for Neglected Diseases initiative (DNDi) is a collaborative, patients' needs-driven, non-profit drug research and development (R&D) organization that is developing new treatments for neglected diseases, notably leishmaniasis, sleeping sickness (human African trypanosomiasis, HAT), Chagas disease, [1] malaria, filarial ...
Benznidazole is the primary treatment of choice for Chagas disease, is produced in Latin America where the disease originates and is most prevalent, at the public pharma LAFEPE in Brasil. Mundo Sano and the Chemo Pharmaceutical Group developed a second generic version of benznidazole , which is manufactured by the Argentine company Laboratorio ...
People with chronic Chagas disease may develop organ dysfunction, which most commonly involves the heart or the digestive system. Chagas disease can be treated using the antiparasitic drugs benznidazole and nifurtimox, which are most effective in the early stage of infection. It is estimated that 6.5 million people worldwide are living with the ...