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Nevirapine (NVP), sold under the brand name Viramune among others, is a medication used to treat and prevent HIV/AIDS, specifically HIV-1. [5] It is generally recommended for use with other antiretroviral medications . [ 5 ]
The studies established the efficacy of Nevirapine in preventing maternal-newborn transmission of HIV. [2] Miiro and his colleagues were able to demonstrate a 50 percent reduction in perinatal transmission to children born to HIV positive mothers, when the mothers are given a single dose of Nevirapine during labor. [3]
"Nevirapine resistance by timing of HIV type 1 infection in infants treated with single-dose nevirapine". ... on the selection of nevirapine-resistant HIV-1 in women ...
All newborns who were exposed to HIV in utero should receive postpartum antiretroviral drugs within 6 hours of delivery, and their dosing should be based on the newborn's gestational age. Premature newborns should only receive zidovudine, lamivudine, and/or nevirapine based on toxicity testing. [48]
Both efavirenz and nevirapine showed similar benefits when combined with NRTI respectively. [55] In the case of the protease inhibitor based regimens, ritonavir is used at low doses to inhibit cytochrome p450 enzymes and "boost" the levels of other protease inhibitors, rather than for its direct antiviral effect.
Lamivudine/nevirapine/stavudine (3TC/NVP/d4T) is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. [1] It contains lamivudine , nevirapine , and stavudine . [ 1 ] It is either used by itself or along with other antiretrovirals . [ 1 ]
The WHO Model List of Essential Medicines for Children (aka Essential Medicines List for Children [1] or EMLc [1]), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe in children up to twelve years of age to meet the most important needs in a health system.
In 1999, an NIAID-funded study in Uganda found that two oral doses of the inexpensive drug nevirapine—one given to HIV-infected mothers at the onset of labor and another to their infants soon after birth—reduced MTCT by half when compared with a similar course of AZT. Subsequent clinical trials, including some funded by NIAID, showed that ...