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Chuvash erythrocytosis or Chuvash polycythemia is an autosomal recessive form of erythrocytosis endemic in patients from the Chuvash Republic in Russia. Chuvash erythrocytosis is associated with homozygosity for a C598T mutation in the von Hippel–Lindau gene ( VHL ), which is needed for the destruction of hypoxia-inducible factors in the ...
In addition, erythropoietin is bound by circulating red blood cells; low circulating numbers lead to a relatively high level of unbound erythropoietin, which stimulates production in the bone marrow. Recent studies have also shown that the peptide hormone hepcidin may play a role in the regulation of hemoglobin production, and thus affect ...
A normocytic anemia is an anemia with a mean corpuscular volume (MCV) of 80–100. Paroxysmal nocturnal hemoglobinuria: D59.5: 9688: Paroxysmal nocturnal hemoglobinuria (also known as Marchiafava-Micheli syndrome) is a rare, acquired, life-threatening blood disease, with anemia due to red blood cell destruction, red urine, and thrombosis.
Erythropoietin (/ ɪ ˌ r ɪ θ r oʊ ˈ p ɔɪ. ɪ t ɪ n , - r ə -, - p ɔɪ ˈ ɛ t ɪ n , - ˈ iː t ɪ n / ; [ 1 ] [ 2 ] [ 3 ] EPO ), also known as erythropoetin , haematopoietin , or haemopoietin , is a glycoprotein cytokine secreted mainly by the kidneys in response to cellular hypoxia ; it stimulates red blood cell production ...
In oncology, polycythemia vera (PV) is an uncommon myeloproliferative neoplasm in which the bone marrow makes too many red blood cells. [1] The majority of cases [2] are caused by mutations in the JAK2 gene, most commonly resulting in a single amino acid change in its protein product from valine to phenylalanine at position 617.
A reference range is usually defined as the set of values 95 percent of the normal population falls within (that is, 95% prediction interval). [2] It is determined by collecting data from vast numbers of laboratory tests. [citation needed]
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There are other names for the hematocrit, such as packed cell volume (PCV), volume of packed red cells (VPRC), or erythrocyte volume fraction (EVF). The term hematocrit (or haematocrit in British English) comes from the Ancient Greek words haima (αἷμα, "blood") and kritēs (κριτής, "judge"), and hematocrit means "to separate blood".